Autograph manuscript.

4to. 1 pp. on 1 bifolium and 1 single leaf. Notes on silkworm disease. Pasteur compiled the present notes in the Swiss Alps in 1857 with the help of observations made by a silkworm breeder. They contain comparative information on the disease afflicting silkworms and diseases of vineyards and mulberry trees: "Note sur les ducations de vers soie destin e la confection de la graine, faite en 1857 dans la Suisse, les montagnes des Basses-Alpes et d'autres localit s o l' pid mie n'a pas paru; par M. Gu rin [illegible]. [ ]". Undoubtedly, Pasteur relied on these notes and other accounts when he travelled to the south of France in 1865 to investigate the diseases among silkworms wreaking havoc in the French silk industry, as he had no prior knowledge of the silkworm disease he was comissioned to investigate. Within three years he succeeded in isolating the bacilli of two distinct diseases and in finding a procedure to prevent contagion as well as in detecting diseased stock. - Slight marginal soiling, otherwise in mint condition.